TRIAL INFORMATION

For more information regarding participation in the LOLIPOP trial please click here


RESEARCH AT RPH ANAESTHESIA

Recent publications originating from or contributed to by RPH anaesthesia

  • Restrictive versus liberal fluid therapy for major abdominal surgery (RELIEF). N Engl J Med 2018; 378:2263-2274, doi: 10.1056/NEJMoa1801601
  • Preoperative gastric residual volumes in fasted patients measured by bedside ultrasound. Anaesth Intensive Care 2018; 46(6):608-613, available here
  • A second look at the second gas effect. Anesthesiology. 2018 Jun;128(6):1053-1054, doi: 10.1097/ALN.0000000000002206
  • Can mathematical modelling explain the measured magnitude of the second gas effect? Anesthesiology. 2018 Jun;128(6):1075-1083, doi: 10.1097/ALN.0000000000002131
  • Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety. Pain. 2018 May 1 (ePub ahead of print), doi: 10.1097/j.pain.0000000000001273
  • Pregabalin to prevent chronic whiplash pain – study protocol for a feasibility study. Trials. 2018 Jan 17;19(1):44, doi: 10.1186/s13063-018-2450-9
  • The pharmacokinetics and local tolerability of a novel sublingual formulation of buprenorphine. Pain Med. 2018 Jan 3, doi: 10.1093/pm/pnx321
  • Hyperbaric oxygen therapy is not associated with oxidative stress. Prostaglandins Leukot Essent Fatty Acids. 2017 Dec;127:16-19, doi: 10.1016/j.plefa.2017.10.003
  • Risk stratification for the development of chronic postsurgical pain. Pain Rep. 2017 Nov; 2(6): e627, doi: 10.1097/PR9.0000000000000627
  • Surgical pleth index: prediction of postoperative pain in children? Br J Anaesth. 2017 Nov 1;119(5):979-983, doi: 10.1093/bja/aex300
  • Monitoring nociception – getting ‘there yet’ might be easier with a road map [editorial]. BJA. 2017 Oct;119(4):716-717, doi:10.1093/bja/aex277
  • The safety profile of parecoxib for the treatment of postoperative pain.  J Pain Res. 2017 Oct 10;10:2451-2459, doi: 10.2147/JPR.S136052
  • Fentanyl formulations in the management of pain: an update. Drugs. 2017 May;77(7):747-763, doi: 10.1007/s40265-017-0727-z
  • The opioid epidemic and national guidelines for opioid therapy for chronic non-cancer pain. Pain Rep. 2017 May; 2(3): e599, doi: 10.1097/PR9.0000000000000599
  • Apneic oxygenation during prolonged laryngoscopy in obese patients. Anesth Analg. 2017 Apr;124(4):1162-1167, doi: 10.1213/ANE.0000000000001564
  • Safety of perioperative glucocorticoids in elective non-cardiac surgery. Anesthesiology. 2017 Feb;126(2):234-248, doi: 10.1097/ALN.0000000000001466
  • Surgical pleth index: prediction of postoperative pain and influence of arousal. Br J Anaesth. 2016 Sep;117(3):371-4, doi: 10.1093/bja/aew226
  • Pregabalin for the treatment of drug and alcohol withdrawal symptoms. CNS Drugs. 2016; 30(12): 1191–1200, doi:  10.1007/s40263-016-0390-z
  • High-flow humidified nasal oxygenation vs. standard face mask oxygenation. Anaesthesia. 2016 Nov;71(11):1280-1283, doi: 10.1111/anae.13607
  • Baroreflex impairment and morbidity after major surgery. Br J Anaesth. 2016 Sep;117(3):324-31, doi: 10.1093/bja/aew257

Research projects underway at RPH anaesthesia

  • ROCKET; reduction of chronic post-surgical pain with ketamine. Trial registration available here
  • LOLIPOP (pilot); long-term outcomes after lignocaine infusion infusions for post-operative pain. Trial registration available here
  • PADDI (incl. PADDI-GENOMICS, PADDI-BRS, PADDI-PONV, PADDI-SLEEP STUDY); perioperative administration of dexamethasone and infection. Trial registration available here
  • BALANCED; the influence of anaesthetic depth on patient outcome after major surgery. Trial registration available here
  • PADDAG; the perioperative administration of dexamethasone and glucose. Trial registration available here
  • Glottic O2; airway oxygen concentration during administration of buccal oxygen. Trial registration available here
  • ACDC; assessment of the accuracy of the oesophageal detector device. Animal study – RPH Wet Lab
  • SLASH; assessing the success rates of cannula and scalpel techniques as the first approach in CICO. Animal study – RPH Wet Lab
  • HipScope2; does the use of muscle relaxants during anaesthesia for hip arthroscopies influence the pressure on the perineum? Trial registration available here
  • HipTraction; the impact of neuromuscular blocking agents on traction forces during total hip replacement surgery. Trial registration available here
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